Sodium Bicarbonate → 2-Amino-5-chloro-2'-hydroxybenzophenone

HRID 1419052

反応式

HRID 1419052 の反応式
[NH2:1][C:2]1[CH:17]=[CH:16][C:15]([Cl:18])=[CH:14][C:3]=1[C:4]([C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=1[O:12]C)=[O:5].C(=O)(O)[O-].[Na+]>Br>[NH2:1][C:2]1[CH:17]=[CH:16][C:15]([Cl:18])=[CH:14][C:3]=1[C:4]([C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=1[OH:12])=[O:5]

参加物

4

反応物 2

HCID 516892Sodium BicarbonateHCID 12325893(2-Amino-5-chlorophenyl)(2-methoxyphenyl)methanone

生成物 1

HCID 5264882-Amino-5-chloro-2'-hydroxybenzophenone収率 93.4%

試薬・触媒・溶媒 1

HCID 260Hydrogen Bromide溶媒

実験手順

A mixture of 2.15 g of 2-amino-5-chloro-2'-methoxybenzophenone and 20 ml of 47% hydrogen bromide was heated for 1 hour under reflux. The solution was rendered neutral with sodium bicarbonate, and subjected to extraction with 100 ml of ethyl acetate. The extract solution was washed with water and dried over anhydrous magnesium sulfate; the solvent was then distilled off under reduced pressure. The residue was purified by means of silica gel column chromatography (eluent, hexane:ethyl acetate=10:1) to yield 1.9 g of 2-amino-5-chloro-2'-hydroxybenzophenone as needles, m.p. 51° to 52° C.

後処理

  1. temperaturewas heated for 1 hour
  2. temperatureunder reflux
  3. extractionsubjected to extraction with 100 ml of ethyl acetate
  4. washThe extract solution was washed with water
  5. dry with materialdried over anhydrous magnesium sulfate
  6. distillationthe solvent was then distilled off under reduced pressure
  7. customThe residue was purified by means of silica gel column chromatography (eluent, hexane:ethyl acetate=10:1)

出典と根拠

ORDレコード
ord-d01087cfaaa64c68b04c9f5897c61b8a
出典データセット
uspto-grants-1999_03
特許番号
US05885979

関連ノート

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