4-Methoxy-N-methyl-2-nitrobenzenamine → 4-methoxy-1-N-methylbenzene-1,2-diamine

HRID 1419121ノート

反応式

HRID 1419121 の反応式
[CH3:1][NH:2][C:3]1[CH:8]=[CH:7][C:6]([O:9][CH3:10])=[CH:5][C:4]=1[N+:11]([O-])=O.[H][H]>C(O)C.[Pd]>[CH3:10][O:9][C:6]1[CH:7]=[CH:8][C:3]([NH:2][CH3:1])=[C:4]([NH2:11])[CH:5]=1

参加物

5

反応物 2

HCID 35543134-Methoxy-N-methyl-2-nitrobenzenamineHCID 178418361HCID 178418361、化合物

生成物 1

HCID 45184444-methoxy-1-N-methylbenzene-1,2-diamine収率 120.7%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

A solution of 1.16 g of N-methyl-4-methoxy-2-nitroaniline (prepared as described in Preparation 24) in 50 ml of ethanol was shaken in an atmosphere of hydrogen and in the presence of 0.3 g of 10% w/w palladium-on-charcoal for 3 hours. At the end of this time, the palladium-on-charcoal was filtered off, and the filtrate was freed from the solvent by evaporation under reduced pressure, to give 1.17 g of the title compound having an Rf value=0.50 (on thin layer chromatography on silica gel; developing solvent: a 1:3 by volume mixture of ethyl acetate and hexane).

後処理

  1. filtrationAt the end of this time, the palladium-on-charcoal was filtered off
  2. customthe filtrate was freed from the solvent by evaporation under reduced pressure

出典と根拠

ORDレコード
ord-790199ed0285429981c03c15091e4c96
出典データセット
uspto-grants-1999_03
特許番号
US05886014

反応ノート

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