Thionyl Chloride → (S)-2-(4-difluoromethoxyphenyl)-3-methylbutyryl chloride
反応式
S(Cl)([Cl:3])=O.[F:5][CH:6]([F:21])[O:7][C:8]1[CH:13]=[CH:12][C:11]([C@H:14]([CH:18]([CH3:20])[CH3:19])[C:15](O)=[O:16])=[CH:10][CH:9]=1>>[F:5][CH:6]([F:21])[O:7][C:8]1[CH:13]=[CH:12][C:11]([C@H:14]([CH:18]([CH3:20])[CH3:19])[C:15]([Cl:3])=[O:16])=[CH:10][CH:9]=1参加物
3
実験手順
Add 32.8 g (0.275 mole) of thionyl chloride to 42 g (0.17 mole) of the obtained (S)-2-(4-difluoromethoxyphenyl)-3-methylbutyric acid, heat with stirring under reflux for 8 hours, and then distill off the unreacted thionyl chloride to give 42.5 g of (S)-2-(4-difluoromethoxyphenyl)-3-methylbutyryl chloride.
後処理
- temperatureheat
- temperatureunder reflux for 8 hours
- distillationdistill off the unreacted thionyl chloride
出典と根拠
- ORDレコード
- ord-15d06c6133944978a6a83231f9ffa369
- 出典データセット
- uspto-grants-1999_03
- 特許番号
- US05886207
反応ノート
読み込み中…