Ethyl Acetate → 7-Amino-4-chloro-6-fluoro-2-methylbenzothiazole

HRID 1419711ノート

反応式

HRID 1419711 の反応式
[Cl:1][C:2]1[C:7]2[N:8]=[C:9]([CH3:11])[S:10][C:6]=2[C:5]([N+:12]([O-])=O)=[C:4]([F:15])[CH:3]=1.C(OCC)(=O)C>O.Cl.[Fe]>[NH2:12][C:5]1[C:6]2[S:10][C:9]([CH3:11])=[N:8][C:7]=2[C:2]([Cl:1])=[CH:3][C:4]=1[F:15]

参加物

6

反応物 2

HCID 8857Ethyl AcetateHCID 537041054-Chloro-6-fluoro-2-methyl-7-nitrobenzothiazole

生成物 1

HCID 537099237-Amino-4-chloro-6-fluoro-2-methylbenzothiazole

試薬・触媒・溶媒 3

HCID 23925Iron触媒HCID 313Hydrochloric Acid溶媒HCID 962Water溶媒

反応条件

温度
80 °C

実験手順

6 g of iron powder were added to a suspension of 8 g (32 mmol) of 4-chloro-6-fluoro-2-methyl-7-nitrobenzothiazole in 100 ml of water and 9 ml of concentrated hydrochloric acid, which suspension had been heated to 80° C., after which the mixture was refluxed for 3 hours. 200 ml of ethyl acetate were then added to the reaction mixture. The solid was filtered off. The remaining organic phase was washed with water, dried over magnesium sulfate and finally evaporated down. Yield: 4.5 g.

後処理

  1. temperatureafter which the mixture was refluxed for 3 hours
  2. filtrationThe solid was filtered off
  3. washThe remaining organic phase was washed with water
  4. dry with materialdried over magnesium sulfate
  5. customfinally evaporated down

出典と根拠

ORDレコード
ord-37de1006222e41ceac0e5112e086f55f
出典データセット
uspto-grants-1999_03
特許番号
US05888940

反応ノート

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