Methanol → Sulindac Sulfide Methyl Ester

HRID 1420720ノート

反応式

HRID 1420720 の反応式
[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)/[C:7](=[CH:11]\[C:12]1[CH:17]=[CH:16][C:15]([S:18][CH3:19])=[CH:14][CH:13]=1)/[C:6]([CH3:20])=[C:5]2[CH2:21][C:22]([OH:24])=[O:23].S(Cl)(Cl)=O.[CH3:29]O>>[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)/[C:7](=[CH:11]\[C:12]1[CH:17]=[CH:16][C:15]([S:18][CH3:19])=[CH:14][CH:13]=1)/[C:6]([CH3:20])=[C:5]2[CH2:21][C:22]([O:24][CH3:29])=[O:23]

参加物

4

反応物 3

HCID 887MethanolHCID 24386Thionyl ChlorideHCID 5352624Sulindac Sulfide

生成物 1

HCID 16046334Sulindac Sulfide Methyl Ester

実験手順

To a suspension of (Z)-5-fluoro-2-methyl-1-(4-methylthiobenzylidene)inden-3-ylacetic acid (51 g, 0.15 mol) in methanol (600 mL) at 0° C. there was slowly added thionyl chloride (26.8 g, 0.225 mol). The mixture was then stirred at room temperature for 2 hours and filtered to afford the title compound as a yellow solid, mp 73-75° C.

後処理

  1. filtrationfiltered

出典と根拠

ORDレコード
ord-55a10ff20b5b48ae9ef5fd2dcb3395ac
出典データセット
uspto-grants-2000_06
特許番号
US06071934

反応ノート

読み込み中…