Thionyl Chloride → 2-Chloro-4-(chloromethyl)-6-methoxypyridine hydrochloride
反応式
S(Cl)([Cl:3])=O.[Cl:5][C:6]1[CH:11]=[C:10]([CH2:12]O)[CH:9]=[C:8]([O:14][CH3:15])[N:7]=1>C1(C)C=CC=CC=1>[ClH:3].[Cl:5][C:6]1[CH:11]=[C:10]([CH2:12][Cl:3])[CH:9]=[C:8]([O:14][CH3:15])[N:7]=1参加物
4
実験手順
Thionyl chloride (1.0 ml) was added to a solution of 2-chloro-4-hydroxymethyl-6-methoxypyridine (0.9 g, 5.2 mmol) in toluene (10 ml) and the mixture stirred at ambient temperature for 1 hour. The volatiles were removed by evaporation, the residue was azeotroped with toluene and dried under vacuum to give 2-chloro-4-chloromethyl-6-methoxypyridine hydrochloride (0.88 g, 74%).
後処理
- customThe volatiles were removed by evaporation
- customthe residue was azeotroped with toluene
- customdried under vacuum
出典と根拠
- ORDレコード
- ord-6d2bc98f1f244cddad787aacc606a7bc
- 出典データセット
- uspto-grants-2000_06
- 特許番号
- US06071921
反応ノート
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