Toluene → 6-Methoxy-7-(2-(methylamino)ethoxy)-3-((pivaloyloxy)methyl)-3,4-dihydroquinazolin-4-one

HRID 1421048ノート

反応式

HRID 1421048 の反応式
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:12]=1[O:13][CH2:14][CH2:15][N:16](C)[C:17](C(C)(C)C)=O)[N:9]=[CH:8][N:7]([CH2:24][O:25][C:26](=[O:31])[C:27]([CH3:30])([CH3:29])[CH3:28])[C:6]2=[O:32].C1(C)C=CC=CC=1>C(Cl)Cl.C(O)(C(F)(F)F)=O>[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:12]=1[O:13][CH2:14][CH2:15][NH:16][CH3:17])[N:9]=[CH:8][N:7]([CH2:24][O:25][C:26](=[O:31])[C:27]([CH3:28])([CH3:30])[CH3:29])[C:6]2=[O:32]

参加物

5

反応物 2

HCID 1140TolueneHCID 226249226-methoxy-7-(2-(N-methyl-N-(t-butylcarbonyl)amino)ethoxy)-3-((pivaloyloxy)methyl)-3,4-dihydroquinazolin-4-one

生成物 1

HCID 226249706-Methoxy-7-(2-(methylamino)ethoxy)-3-((pivaloyloxy)methyl)-3,4-dihydroquinazolin-4-one収率 73.4%

試薬・触媒・溶媒 2

HCID 6344Dichloromethane溶媒HCID 6422Trifluoroacetic acid溶媒

実験手順

A solution of 6-methoxy-7-(2-(N-methyl-N-(t-butylcarbonyl)amino)ethoxy)-3-((pivaloyloxy)methyl)-3,4-dihydroquinazolin-4-one (1.39 g, 3 mmol) in methylene chloride (4 ml) and TFA (4 ml) was stirred at ambient temperature for 1 hour. Toluene was added, and the volatiles were removed by evaporation. The residue was triturated with ether and the resulting solid was collected by filtration. The solid was dissolved in water, sodium hydrogen carbonate was added and the aqueous mixture was extracted with methylene chloride. The organic extract was dried (MgSO4) and the solvent removed by evaporation. The residue was triturated with ether and the solid was collected by filtration to give 6-methoxy-7-(2-(methylamino)ethoxy)-3-((pivaloyloxy)methyl)-3,4-dihydroquinazolin4-one (800 mg, 73%).

後処理

  1. customthe volatiles were removed by evaporation
  2. customThe residue was triturated with ether
  3. filtrationthe resulting solid was collected by filtration
  4. dissolutionThe solid was dissolved in water
  5. additionsodium hydrogen carbonate was added
  6. extractionthe aqueous mixture was extracted with methylene chloride
  7. extractionThe organic extract
  8. dry with materialwas dried (MgSO4)
  9. customthe solvent removed by evaporation
  10. customThe residue was triturated with ether
  11. filtrationthe solid was collected by filtration

出典と根拠

ORDレコード
ord-de9926a9b9f74fa8bfd11ec04c243214
出典データセット
uspto-grants-2000_06
特許番号
US06071921

反応ノート

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