Ethyl Acetoacetate → Ethyl alpha-acetyl-4-methoxybenzenepropanoate

HRID 1421254ノート

反応式

HRID 1421254 の反応式
[C:1]([O:7][CH2:8][CH3:9])(=[O:6])[CH2:2][C:3]([CH3:5])=[O:4].[CH3:10][O:11][C:12]1[CH:19]=[CH:18][C:15]([CH2:16]Cl)=[CH:14][CH:13]=1.N12CCCN=C1CCCCC2>CC#N>[CH2:8]([O:7][C:1](=[O:6])[CH:2]([CH2:16][C:15]1[CH:18]=[CH:19][C:12]([O:11][CH3:10])=[CH:13][CH:14]=1)[C:3](=[O:4])[CH3:5])[CH3:9]

参加物

5

反応物 3

HCID 8868Ethyl AcetoacetateHCID 699934-Methyloxybenzyl chlorideHCID 811841,8-Diazabicyclo(5.4.0)undec-7-ene

生成物 1

HCID 12248936Ethyl alpha-acetyl-4-methoxybenzenepropanoate

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

A solution of ethyl acetoacetate and 4-methoxybenzyl chloride is stirred under an argon atmosphere with 1,8-diazabicyclo[5.4.0]undec-7-ene at room temperature in CH3CN. The mixture is partitioned between 3 N HCl and EtOAc. The organic extract is washed successively with H2O, aqueous NaHCO3, H2O and saturated aqueous NaCl and dried (Na2SO4). The solvent is removed in vacuo to afford the title compound.

後処理

  1. customThe mixture is partitioned between 3 N HCl and EtOAc
  2. extractionThe organic extract
  3. washis washed successively with H2O, aqueous NaHCO3, H2O and saturated aqueous NaCl
  4. dry with materialdried (Na2SO4)
  5. customThe solvent is removed in vacuo

出典と根拠

ORDレコード
ord-2e56d6cfdea142a6a9c8557bf84d89fb
出典データセット
uspto-grants-2000_06
特許番号
US06075037

反応ノート

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