Benzoyl chloride → 3-(Phenylformamido)butanoic acid
反応式
[NH2:1][CH:2]([CH3:7])[CH2:3][C:4]([OH:6])=[O:5].[C:8](Cl)(=[O:15])[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1>[OH-].[Na+]>[C:8]([NH:1][CH:2]([CH3:7])[CH2:3][C:4]([OH:6])=[O:5])(=[O:15])[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1参加物
4
実験手順
To a cooled solution of 3-aminobutyric acid (13 g) in 2M NaOH (130 ml) is added benzoyl chloride (19.7 g) over the course of two hours. The mixture is allowed to warm to room temperature. Washing with diethyl ether, acidifying the aqueous phase with 20% HCl, extracting with diethyl ether, drying over MgSO4, evaporating the solvent and recrystallizing in either/hexane gives the title compound m.p. 150-152° C. (Compound 1.6, Table 1).
後処理
- washWashing with diethyl ether
- extractionextracting with diethyl ether
- dry with materialdrying over MgSO4
- customevaporating the solvent
- customrecrystallizing in either/hexane
出典と根拠
- ORDレコード
- ord-455bf8fa641a41c9a857bedaf74b016c
- 出典データセット
- uspto-grants-2000_06
- 特許番号
- US06075051
反応ノート
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