Methanol → Maribavir

HRID 1421480ノート

反応式

HRID 1421480 の反応式
[Cl:1][C:2]1[C:32]([Cl:33])=[CH:31][C:5]2[N:6]([C@H:13]3[O:25][C@@H:24]([CH2:26][O:27]C(=O)C)[C@H:19]([O:20]C(=O)C)[C@@H:14]3[O:15]C(=O)C)[C:7]([NH:9][CH:10]([CH3:12])[CH3:11])=[N:8][C:4]=2[CH:3]=1.C(=O)([O-])[O-].[Na+].[Na+].O.CO>C(O)C>[Cl:1][C:2]1[C:32]([Cl:33])=[CH:31][C:5]2[N:6]([C@H:13]3[O:25][C@@H:24]([CH2:26][OH:27])[C@H:19]([OH:20])[C@@H:14]3[OH:15])[C:7]([NH:9][CH:10]([CH3:11])[CH3:12])=[N:8][C:4]=2[CH:3]=1

参加物

6

反応物 4

HCID 887MethanolHCID 962WaterHCID 10340Sodium CarbonateHCID 53780792HCID 53780792、化合物

生成物 1

HCID 471161Maribavir収率 84%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

5,6-Dichloro-2-(isopropylamino)-1-(2,3,5-tri-O-acetyl-beta-L-ribofuranosyl)-1H-benzimidazole (7.50 g, 14.93 mmol), sodium carbonate (1.72 g, 16.23 mmol), water (29 mL), methanol (100 mL) and ethanol (100 mL) were used according to general procedure III. The product was purified by silica gel chromatography using 55:45 dichloromethanelmethanol to afford 4.72 g (84%) of a white foam. Analytical data were consistent with the assigned structure.

後処理

  1. customThe product was purified by silica gel chromatography

出典と根拠

ORDレコード
ord-50b746d9c2224bec924adf992107661f
出典データセット
uspto-grants-2000_06
特許番号
US06077832

反応ノート

読み込み中…