Water → 4-((methylthio)methyl)benzonitrile(WX192182)
反応式
C(#N)C.[C:4]([C:6]1[CH:13]=[CH:12][C:9]([CH2:10]Br)=[CH:8][CH:7]=1)#[N:5].[Na].[CH3:15][SH:16].O>C1(C)C=CC=CC=1>[CH3:15][S:16][CH2:10][C:9]1[CH:12]=[CH:13][C:6]([C:4]#[N:5])=[CH:7][CH:8]=1参加物
6
実験手順
To an acetonitrile solution (500 ml) of 4-cyanobenzyl bromide (50 g), 15% methyl mercaptan sodium salt (120 ml) was added at a room temperature and heated for 6 hours with refluxing. After cooling to a room temperature, water (1 l) and toluene (1 l) was added thereto. The organic layer was separated and washed successively with an aqueous 2N sodium hydroxide solution sulfate. After distilling off the solvent, 4-methylmercaptomethylbenzonitrile (38 g) was obtained.
後処理
- temperatureheated for 6 hours
- temperaturewith refluxing
- customThe organic layer was separated
- washwashed successively with an aqueous 2N sodium hydroxide solution sulfate
- distillationAfter distilling off the solvent
出典と根拠
- ORDレコード
- ord-4244a8160d83451cabf1a5ebea20c65c
- 出典データセット
- uspto-grants-2000_06
- 特許番号
- US06077866
反応ノート
読み込み中…