Cyclohexene → HCID 385194、化合物

HRID 1421877ノート

反応式

HRID 1421877 の反応式
[NH2:1][C:2]1[N:7]=[C:6]([NH:8][CH2:9][C:10]2([CH2:14][OH:15])[CH2:13][CH2:12][CH2:11]2)[CH:5]=[C:4](Cl)[N:3]=1.C1CCCCC=1>[OH-].[Pd+2].[OH-].C(O)C>[NH2:1][C:2]1[N:7]=[C:6]([NH:8][CH2:9][C:10]2([CH2:14][OH:15])[CH2:13][CH2:12][CH2:11]2)[CH:5]=[CH:4][N:3]=1

参加物

5

反応物 2

HCID 8079CyclohexeneHCID 385223HCID 385223、化合物

生成物 1

HCID 385194HCID 385194、化合物

試薬・触媒・溶媒 2

HCID 9942167Palladium hydroxide触媒HCID 702Ethanol溶媒

実験手順

To 2-amino-6-chloro-4-[[(1-hydroxymethyl-1-cyclobutyl)methyl]amino]pyrimidine (1.46 g, 6.0 mmol) were added ethanol (40 ml), cyclohexene (15 ml) and palladium hydroxide (0.2 g) in a nitrogen stream, and the mixture was refluxed for 2 hours. The reaction mixture was filtered and the solvent in the filtrate was distilled away under reduced pressure to give white amorphous crystals (1.34 g, quantitative).

後処理

  1. temperaturethe mixture was refluxed for 2 hours
  2. filtrationThe reaction mixture was filtered
  3. distillationthe solvent in the filtrate was distilled away under reduced pressure
  4. customto give white amorphous crystals (1.34 g, quantitative)

出典と根拠

ORDレコード
ord-239085a746b040f697a4476dde4d800f
出典データセット
uspto-grants-2000_06
特許番号
US06080750

反応ノート

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