Hydrazine hydrate (1:1) → 2-Naphthohydrazide
反応式
C([O:3][C:4]([C:6]1[CH:15]=[CH:14][C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[CH:7]=1)=O)C.O.[NH2:17][NH2:18]>C(O)C>[CH:7]1[C:8]2[C:13](=[CH:12][CH:11]=[CH:10][CH:9]=2)[CH:14]=[CH:15][C:6]=1[C:4]([NH:17][NH2:18])=[O:3]参加物
4
実験手順
To a solution of 2-naphthyl carboxylic acid ethyl ester (2.0 g, 9.99 mmol) in absolute ethanol (30 ml) was added hydrazine hydrate (4.85 ml, 99.9 mmol) and the reaction mixture was heated at reflux temperature for 72 h. The reaction mixture was cooled and the precipitate was filtered off, washed with 96% ethanol (2×10 ml) and diethyl ether (3×10 ml), dried in vacuo at 50° C. which afforded 0.9 g (48%) of naphthalene-2-carboxylic acid hydrazide as a solid.
後処理
- temperaturethe reaction mixture was heated
- temperatureat reflux temperature for 72 h
- temperatureThe reaction mixture was cooled
- filtrationthe precipitate was filtered off
- washwashed with 96% ethanol (2×10 ml) and diethyl ether (3×10 ml)
- customdried in vacuo at 50° C. which
出典と根拠
- ORDレコード
- ord-8a6b1a4a528e4c76b289a13586b8a40e
- 出典データセット
- uspto-grants-2000_06
- 特許番号
- US06080770
反応ノート
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