Sodium Hydroxide → 5-Bromoisoquinoline
反応式
N[C:2]1[CH:11]=[CH:10][CH:9]=[C:8]2[C:3]=1[CH:4]=[CH:5][N:6]=[CH:7]2.N([O-])=O.[Na+].[OH-].[Na+].[BrH:18].O>O>[Br:18][C:2]1[CH:11]=[CH:10][CH:9]=[C:8]2[C:3]=1[CH:4]=[CH:5][N:6]=[CH:7]2参加物
6
反応条件
- 温度
- 75 °C
実験手順
To a cold (0° C.) solution of HBr-H2O (48%) (10 ml) in water (30 ml) was added 5-aminoisoquinoline (5 g; 35 mmol) followed by sodium nitrite (2.4 g; 35 mmol) in water (20 ml). The mixture was added to a warm (75° C.) solution of cuprous bromide (5 g; 35 mmol) in HBr-H2O (48%) (50 ml) and stirred overnight at 75° C. The reaction mixture was cooled, basified to pH11 with NaOH (5 M) and steamed distilled to afford the title compound (1.4 g) as a colourless crystalline solid (mp 65° C.).
後処理
- additionThe mixture was added to
- temperatureThe reaction mixture was cooled
- distillationsteamed distilled
出典と根拠
- ORDレコード
- ord-09106672b3774edca067e001e238bcb2
- 出典データセット
- uspto-grants-2000_06
- 特許番号
- US06080790
反応ノート
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