Hydrochloric Acid → HCID 54239092、化合物

HRID 1422220ノート

反応式

HRID 1422220 の反応式
Cl.[NH2:2][CH2:3][C:4]1[CH:13]=[C:12]([Br:14])[CH:11]=[C:10]2[C:5]=1[NH:6][C:7](=[O:16])[C:8](=[O:15])[NH:9]2.[CH2:17]([O:19][C:20](=[O:26])/[CH:21]=[CH:22]/[C:23](O)=[O:24])[CH3:18].Cl.CN(C)CCCN=C=NCC.ON1C2C=CC=CC=2N=N1.Cl>CN(C)C=O.O.C(N(CC)CC)C>[CH2:17]([O:19][C:20](=[O:26])[CH:21]=[CH:22][C:23](=[O:24])[NH:2][CH2:3][C:4]1[CH:13]=[C:12]([Br:14])[CH:11]=[C:10]2[C:5]=1[NH:6][C:7](=[O:16])[C:8](=[O:15])[NH:9]2)[CH3:18]

参加物

9

反応物 5

HCID 313Hydrochloric AcidHCID 757711-HydroxybenzotriazoleHCID 27239391,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochlorideHCID 5358902Monoethyl fumarateHCID 18706500HCID 18706500、化合物

生成物 1

HCID 54239092HCID 54239092、化合物

試薬・触媒・溶媒 3

HCID 962Water溶媒HCID 6228Dimethylformamide溶媒HCID 8471Triethylamine溶媒

実験手順

351 mg (1 mmol) of 5-aminomethyl-7-bromo-2,3-dioxo-1,2,3,4-tetrahydroquinoxaline hydrochloride, (Example 2) 217 mg (1.5 equiv.) of fumaric acid monoethyl ester, 0.210 ml of triethylamine, 383 mg (2 equiv.) of N-(3-dimethylaminopropyl)-N'-ethyl-carbodiimide hydrochloride and 270 mg (2 equiv.) of 1-hydroxy-benzotriazole are stirred at 20° C. in dried dimethylformamide for 18 hours. The mixture is poured into 700 ml of water and 3 ml of 1 N hydrochloric acid and stirred for 15 minutes. The solid is filtered off, washed with water and dried.

後処理

  1. filtrationThe solid is filtered off
  2. washwashed with water
  3. customdried

出典と根拠

ORDレコード
ord-9c3287a3d9f44c2989b7becbb0df39e3
出典データセット
uspto-grants-2000_06
特許番号
US06080743

反応ノート

読み込み中…