Lithium hydroxide, monohydrate → HCID 18706397、化合物

HRID 1422225ノート

反応式

HRID 1422225 の反応式
C([O:3][C:4](=[O:21])[C:5]([S:7][CH2:8][C:9]1[CH:18]=[C:17]([Br:19])[CH:16]=[C:15]2[C:10]=1[NH:11][C:12](=[O:20])[CH2:13][NH:14]2)=[O:6])C.O.[OH-].[Li+]>O1CCCC1.O>[Br:19][C:17]1[CH:16]=[C:15]2[C:10]([NH:11][C:12](=[O:20])[CH2:13][NH:14]2)=[C:9]([CH2:8][S:7][C:5](=[O:6])[C:4]([OH:21])=[O:3])[CH:18]=1

参加物

5

反応物 2

HCID 168937Lithium hydroxide, monohydrateHCID 86755474HCID 86755474、化合物

生成物 1

HCID 18706397HCID 18706397、化合物

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 8028Tetrahydrofuran溶媒

反応条件

温度
20 °C

実験手順

500 mg (1.34 mmol) of 7-bromo-2,3-dioxo-1,2,3,4-tetrahydroquinoxalin-5-ylmethylsulfanylacetic acid ethyl ester (Example 18) are suspended in 20 ml of tetrahydrofuran and 10 ml of water, and 225 mg (4 equiv.) of lithium hydroxide hydrate are added. The mixture is stirred at 20° C. for 48 hours. The tetrahydrofuran is concentrated by evaporation, 60 ml of water are added and the solution is acidified with 1 N hydrochloric acid. The solid is filtered off, washed with water and dried.

後処理

  1. concentrationThe tetrahydrofuran is concentrated by evaporation, 60 ml of water
  2. additionare added
  3. filtrationThe solid is filtered off
  4. washwashed with water
  5. customdried

出典と根拠

ORDレコード
ord-47cfb5837d8d4fdb906f857fea5a6755
出典データセット
uspto-grants-2000_06
特許番号
US06080743

反応ノート

読み込み中…