N-(7-bromo-2,3-dimethoxy-quinoxalin-5-ylmethyl)-oxalamic acid ethyl ester → N-(7-Bromo-2,3-dioxo-1,2,3,4-tetrahydroquinoxalin-5-ylmethyl)-oxalamic acid ethyl ester

HRID 1422226ノート

反応式

HRID 1422226 の反応式
[CH2:1]([O:3][C:4](=[O:24])[C:5]([NH:7][CH2:8][C:9]1[CH:18]=[C:17]([Br:19])[CH:16]=[C:15]2[C:10]=1[N:11]=[C:12]([O:22]C)[C:13]([O:20]C)=[N:14]2)=[O:6])[CH3:2]>Br.C(O)(=O)C.C(OCC)C>[CH2:1]([O:3][C:4](=[O:24])[C:5]([NH:7][CH2:8][C:9]1[CH:18]=[C:17]([Br:19])[CH:16]=[C:15]2[C:10]=1[NH:11][C:12](=[O:22])[C:13](=[O:20])[NH:14]2)=[O:6])[CH3:2]

参加物

5

反応物 1

HCID 54297612N-(7-bromo-2,3-dimethoxy-quinoxalin-5-ylmethyl)-oxalamic acid ethyl ester

生成物 1

HCID 54187739N-(7-Bromo-2,3-dioxo-1,2,3,4-tetrahydroquinoxalin-5-ylmethyl)-oxalamic acid ethyl ester

試薬・触媒・溶媒 3

HCID 176Acetic Acid溶媒HCID 260Hydrogen Bromide溶媒HCID 3283Diethyl Ether溶媒

実験手順

254 mg (0.79 mmol) of N-(7-bromo-2,3-dimethoxy-quinoxalin-5-ylmethyl)-oxalamic acid ethyl ester are dissolved in 6 ml of an approximately 25% solution of hydrogen bromide in acetic acid, and the solution is stirred at room temperature for 16 hours. The mixture is diluted with diethyl ether, and the solid is filtered off and washed with diethyl ether. After drying under a high vacuum, the title compound is obtained in the form of a beige solid.

後処理

  1. filtrationthe solid is filtered off
  2. washwashed with diethyl ether
  3. customAfter drying under a high vacuum

出典と根拠

ORDレコード
ord-26280e28dc9f4fdab09f13129e2a8242
出典データセット
uspto-grants-2000_06
特許番号
US06080743

反応ノート

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