Acetic Anhydride → N-(2,3-Dimethoxy-7-nitro-quinoxalin-5-ylmethyl)-acetamide

HRID 1422232ノート

反応式

HRID 1422232 の反応式
[NH2:1][CH2:2][C:3]1[CH:12]=[C:11]([N+:13]([O-:15])=[O:14])[CH:10]=[C:9]2[C:4]=1[N:5]=[C:6]([O:18][CH3:19])[C:7]([O:16][CH3:17])=[N:8]2.BrCC1C=C([N+]([O-])=O)C=C2C=1N=[C:25](OC)[C:26]([O:35]C)=N2.C(OC(=O)C)(=O)C.C(N(CC)CC)C>C(N(CC)C=O)C.C(OCC)C>[CH3:17][O:16][C:7]1[C:6]([O:18][CH3:19])=[N:5][C:4]2[C:9](=[CH:10][C:11]([N+:13]([O-:15])=[O:14])=[CH:12][C:3]=2[CH2:2][NH:1][C:26](=[O:35])[CH3:25])[N:8]=1

参加物

7

反応物 4

HCID 7918Acetic AnhydrideHCID 8471TriethylamineHCID 179152965-Aminomethyl-2,3-dimethoxy-7-nitro-quinoxalineHCID 232979835-Bromomethyl-7-nitro-2,3-dimethoxyquinoxaline

生成物 1

HCID 18706427N-(2,3-Dimethoxy-7-nitro-quinoxalin-5-ylmethyl)-acetamide

試薬・触媒・溶媒 2

HCID 3283Diethyl Ether溶媒HCID 12051Diethylformamide溶媒

実験手順

111 mg (0.437 mmol) of 5-aminomethyl-2,3-dimethoxy-7-nitro-quinoxaline, obtainable in a manner analogous to that described in Example 9 but starting from 5-bromomethyl-2,3-dimethoxy-7-nitro-quinoxaline, are stirred with 0.046 ml (1.1 equiv.) of acetic anhydride and 0.073 ml (1.2 equiv.) of triethylamine in 5 ml of N,N-diethylformamide at room temperature for 24 hours. The reaction mixture is diluted with diethyl ether, and the solid is filtered off, washed with diethyl ether and dried.

後処理

  1. filtrationthe solid is filtered off
  2. washwashed with diethyl ether
  3. customdried

出典と根拠

ORDレコード
ord-390f1566680049a9818d0fcf93d57184
出典データセット
uspto-grants-2000_06
特許番号
US06080743

反応ノート

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