HCID 59484893、化合物 → 6-(5-methyloxazol-2-yl)-2H-pyridazin-3-one

HRID 1422663ノート

反応式

HRID 1422663 の反応式
[CH2:1]([NH:4][C:5]([C:7]1[CH:12]=[CH:11][C:10](=[O:13])[NH:9][N:8]=1)=[O:6])[C:2]#[CH:3]>C(#N)C.[Au](Cl)(Cl)Cl>[CH3:3][C:2]1[O:6][C:5]([C:7]2[CH:12]=[CH:11][C:10](=[O:13])[NH:9][N:8]=2)=[N:4][CH:1]=1

参加物

4

反応物 1

HCID 59484893HCID 59484893、化合物

生成物 1

HCID 594849556-(5-methyloxazol-2-yl)-2H-pyridazin-3-one

試薬・触媒・溶媒 2

HCID 26030Gold trichloride触媒2 回HCID 6342Acetonitrile溶媒

実験手順

622 mg (2.05 mmol) of gold(III) chloride are added to a solution of 3.69 g (20.5 mmol) of N-prop-2-ynyl-6-oxo-1,6-dihydropyridazine-3-carboxamide in 41 ml of acetonitrile, and the mixture is stirred at room temperature for 3 days. A further 622 mg (2.05 mmol) of gold(III) chloride are added, and the mixture is stirred at room temperature for 7 days. The reaction mixture is evaporated and chromatographed on a silica gel column with dichloromethane/methanol as eluent: 6-(5-methyloxazol-2-yl)-2H-pyridazin-3-one as yellowish crystals; ESI 178.

後処理

  1. stirringthe mixture is stirred at room temperature for 7 days
  2. customThe reaction mixture is evaporated
  3. customchromatographed on a silica gel column with dichloromethane/methanol as eluent

出典と根拠

ORDレコード
ord-bcf8bc7525e54ae788b6a05761b5bea5
出典データセット
uspto-grants-2015_01
特許番号
US08927540B2

反応ノート

読み込み中…