HCID 66747421、化合物 → HCID 66747578、化合物
反応式
[CH3:1][O:2][C:3]1[C:4]([N+:16]([O-])=O)=[C:5]([NH:11][CH2:12][C:13](O)=[O:14])[CH:6]=[CH:7][C:8]=1[O:9][CH3:10]>[Pd].CO>[CH3:10][O:9][C:8]1[C:3]([O:2][CH3:1])=[C:4]2[C:5]([NH:11][CH2:12][C:13](=[O:14])[NH:16]2)=[CH:6][CH:7]=1参加物
4
実験手順
10% Palladium on activated carbon (0.22 g, 2.06 mmol, 0.48 eq) is added at room temperature to a stirred solution of (3,4-dimethoxy-2-nitro-phenylamino)-acetic acid (1.1 g, 4.29 mmol, 1.0 eq) in methanol (30 mL). The mixture is hydrogenated for 16 hours, then filtered through decalite. Solvent is removed to afford 7,8-dimethoxy-3,4-dihydro-1H-quinoxalin-2-one as an off-white solid (0.46 g, 52% yield).
後処理
- filtrationfiltered through decalite
- customSolvent is removed
出典と根拠
- ORDレコード
- ord-03402c0b6dc14a9b970551220164742b
- 出典データセット
- uspto-grants-2015_01
- 特許番号
- US08927542B2
反応ノート
読み込み中…