Water → (S)-6-Oxo-piperidine-2-carboxylic acid ((S)-6-mercapto-1-phenylcarbamoyl-hexyl)amide

HRID 1422881ノート

反応式

HRID 1422881 の反応式
[OH-].[Na+].[O:3]=[C:4]1[NH:9][C@H:8]([C:10]([NH:12][C@H:13]([C:23](=[O:31])[NH:24][C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)[CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][S:19]C(=O)C)=[O:11])[CH2:7][CH2:6][CH2:5]1.O>CCO>[SH:19][CH2:18][CH2:17][CH2:16][CH2:15][CH2:14][C@H:13]([NH:12][C:10]([C@@H:8]1[CH2:7][CH2:6][CH2:5][C:4](=[O:3])[NH:9]1)=[O:11])[C:23](=[O:31])[NH:24][C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1

参加物

5

反応物 3

HCID 962WaterHCID 14798Sodium HydroxideHCID 71506894HCID 71506894、化合物

生成物 1

HCID 71538746(S)-6-Oxo-piperidine-2-carboxylic acid ((S)-6-mercapto-1-phenylcarbamoyl-hexyl)amide

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A 2N solution of NaOH (7.0 mmol) was added to a solution of thioacetic acid S—{(S)-6-[((S)-6-oxo-piperidine-2-carbonyl)-amino]-6-phenylcarbamoyl-hexyl}ester (0.95 mmol) in EtOH (13 ml). The reaction mixture was stirred at RT overnight and then poured into water and extracted with AcOEt, washed with water, brine and finally dried over Na2SO4. Removal of the solvent under reduced pressure led to the desired adduct, which was purified through HPLC.

後処理

  1. extractionextracted with AcOEt
  2. washwashed with water, brine
  3. dry with materialfinally dried over Na2SO4
  4. customRemoval of the solvent under reduced pressure
  5. customwas purified through HPLC

出典と根拠

ORDレコード
ord-d7ce9162b904417ea3458f4e33a379d9
出典データセット
uspto-grants-2015_01
特許番号
US08927533B2

反応ノート

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