Hydrazine hydrate (1:1) → 4-bromo-N-(5-(hydrazinecarbonyl)thiophen-3-yl)picolinamide
反応式
[Br:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4]([C:8]([NH:10][C:11]2[CH:12]=[C:13]([C:16]([O:18]C)=O)[S:14][CH:15]=2)=[O:9])[CH:3]=1.O.[NH2:21][NH2:22]>C(O)C>[Br:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4]([C:8]([NH:10][C:11]2[CH:12]=[C:13]([C:16]([NH:21][NH2:22])=[O:18])[S:14][CH:15]=2)=[O:9])[CH:3]=1参加物
4
実験手順
The methyl 4-(4-bromopicolinamido)thiophene-2-carboxylate (2.7 g, 6.9 mmol) was dissolved in ethanol, hydrazine hydrate (1.4 mL, 28 mmol) was added and the reaction was refluxed overnight. The reaction mixture was concentrated, and the solids were suspended in acetonitrile and filtered to afford 2.4 g (70%) 4-bromo-N-(5-(hydrazinecarbonyl)thiophen-3-yl)picolinamide as a white solid. M+1=341.1
後処理
- temperaturethe reaction was refluxed overnight
- concentrationThe reaction mixture was concentrated
- filtrationfiltered
出典と根拠
- ORDレコード
- ord-384b3a68165b4d51885bd65baf8e27b0
- 出典データセット
- uspto-grants-2015_01
- 特許番号
- US08927582B2
反応ノート
読み込み中…