Sodium Hydroxide → 4-Neopentyl-2-nitroaniline
反応式
[CH2:1]([C:6]1[CH:11]=[CH:10][C:9]([NH:12]C(=O)C)=[C:8]([N+:16]([O-:18])=[O:17])[CH:7]=1)[C:2]([CH3:5])([CH3:4])[CH3:3].[OH-].[Na+]>O>[CH2:1]([C:6]1[CH:11]=[CH:10][C:9]([NH2:12])=[C:8]([N+:16]([O-:18])=[O:17])[CH:7]=1)[C:2]([CH3:5])([CH3:4])[CH3:3]参加物
4
反応条件
- 温度
- 90 °C
実験手順
A suspension of N-(4-neopentyl-2-nitrophenyl)acetamide (Preparation 87, 3.0 g, 12.0 mmol) in aqueous sodium hydroxide (6.0 M, 20 mL, 120 mmol) was heated at 90° C. for 36 hours. After cooling, a small amount of water was added and the mixture extracted with dichloromethane (5×). The organic layers were combined, dried over anhydrous magnesium sulphate, filtered, and concentrated in vacuo to provide the title compound (2.15 g, 90%) as a yellow solid.
後処理
- temperatureAfter cooling
- extractionthe mixture extracted with dichloromethane (5×)
- dry with materialdried over anhydrous magnesium sulphate
- filtrationfiltered
- concentrationconcentrated in vacuo
出典と根拠
- ORDレコード
- ord-5f4e2452d9f24f978c3e2aaab21f9e55
- 出典データセット
- uspto-grants-2015_01
- 特許番号
- US08927587B2
反応ノート
読み込み中…