Trifluoroacetic acid → HCID 53932726、化合物

HRID 1424587ノート

反応式

HRID 1424587 の反応式
C(OC([N:8]1[CH2:13][CH2:12][C:11]2([C:21]3[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=3)[CH:15]([CH2:22][C:23]([OH:25])=[O:24])[CH2:14]2)[CH2:10][CH2:9]1)=O)(C)(C)C.FC(F)(F)C(O)=O>C(Cl)Cl>[NH:8]1[CH2:13][CH2:12][C:11]2([C:21]3[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=3)[CH:15]([CH2:22][C:23]([OH:25])=[O:24])[CH2:14]2)[CH2:10][CH2:9]1

参加物

4

反応物 2

HCID 6422Trifluoroacetic acidHCID 23367940[1'-(tert-Butoxycarbonyl)-2,3-dihydrospiro[indene-1,4'-piperidin]-3-yl]acetic acid

生成物 1

HCID 53932726HCID 53932726、化合物収率 112.5%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

2-(1′-(Tert-butoxycarbonyl)-2,3-dihydrospiro[indene-1,4′-piperidine]-3-yl)acetic acid (200 mg, 0.58 mmol) was added to a solution of 20% trifluoroacetic acid in anhydrous CH2Cl2 (3 mL) at 0° C. The reaction solution was stirred at rt for 2 h until the starting material had been consumed. The solution was concentrated to give crude 2-(2,3-dihydrospiro[indene-1,4′-piperidine]-3-yl)acetic acid (160 mg) which was used in the next step without further purification.

後処理

  1. customhad been consumed
  2. concentrationThe solution was concentrated

出典と根拠

ORDレコード
ord-ebbc24a8399d4979a1efa197abe22ea3
出典データセット
uspto-grants-2015_01
特許番号
US08927715B2

反応ノート

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