1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride → tert-Butyl cis(+/-)-4-{[(4-chloro-5-methyl-1H-imidazol-2-yl)carbonyl]amino}-3-ethoxypiperidine-1-carboxylate

HRID 1424916

反応式

HRID 1424916 の反応式
[NH2:1][C@H:2]1[CH2:7][CH2:6][N:5]([C:8]([O:10][C:11]([CH3:14])([CH3:13])[CH3:12])=[O:9])[CH2:4][C@H:3]1[O:15][CH2:16][CH3:17].[Cl:18][C:19]1[N:20]=[C:21]([C:25](O)=[O:26])[NH:22][C:23]=1[CH3:24].CCN=C=NCCCN(C)C.Cl>CN(C1C=CN=CC=1)C>[Cl:18][C:19]1[N:20]=[C:21]([C:25]([NH:1][C@H:2]2[CH2:7][CH2:6][N:5]([C:8]([O:10][C:11]([CH3:12])([CH3:13])[CH3:14])=[O:9])[CH2:4][C@H:3]2[O:15][CH2:16][CH3:17])=[O:26])[NH:22][C:23]=1[CH3:24]

参加物

5

反応物 3

HCID 27239391,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochlorideHCID 144742774-chloro-5-methyl-1H-imidazole-2-carboxylic acid2 回HCID 86648467Tert-butyl cis(+/-)-4-amino-3-ethoxypiperidine-1-carboxylate

生成物 1

HCID 86648466tert-Butyl cis(+/-)-4-{[(4-chloro-5-methyl-1H-imidazol-2-yl)carbonyl]amino}-3-ethoxypiperidine-1-carboxylate収率 43%

試薬・触媒・溶媒 1

HCID 142844-(Dimethylamino)pyridine触媒

実験手順

The same operation as in Example (1g) was performed using tert-butyl cis(±)-4-amino-3-ethoxypiperidine-1-carboxylate obtained in Example (18a) (0.34 g, 1.37 mmol), 4-chloro-5-methyl-1H-imidazole-2-carboxylic acid obtained by the method described in Example (5c) (0.16 g, 0.91 mmol), WSC hydrochloride (1.18 g, 6.15 mmol) and DMAP (0.12 g, 0.94 mmol), to obtain 0.23 g of the title compound as a pale yellow solid (43%).

後処理

  1. customobtained by the method

出典と根拠

ORDレコード
ord-64627184f1df4c649a307fe26ee7b21e
出典データセット
uspto-grants-2015_01
特許番号
US08927588B2

関連ノート

読み込み中…