Ammonia → 2-(dimethoxymethyl)-5-ethyl-4-(trifluoromethyl)-1H-imidazole

HRID 1424943ノート

反応式

HRID 1424943 の反応式
[CH2:1]1[C:6](=O)[N:5](Cl)[C:3](=O)[CH2:2]1.[F:9][C:10]([F:22])([F:21])C(C1(CC)SCCCS1)=O.[CH3:23][O:24][CH:25]([O:28][CH3:29])[CH:26]=O.[NH3:30]>[N+]([O-])([O-])=O.[Ag+]>[CH3:23][O:24][CH:25]([O:28][CH3:29])[C:26]1[NH:30][C:2]([CH2:1][CH3:6])=[C:3]([C:10]([F:22])([F:21])[F:9])[N:5]=1

参加物

6

反応物 4

HCID 222AmmoniaHCID 31398ChlorosuccinimideHCID 162650Acetaldehyde, 2,2-dimethoxy-HCID 866484862,2,2-Trifluoro-1-(2-ethyl-1,3-dithian-2-yl)ethanone

生成物 1

HCID 684060432-(dimethoxymethyl)-5-ethyl-4-(trifluoromethyl)-1H-imidazole

試薬・触媒・溶媒 1

HCID 24470Silver Nitrate触媒

実験手順

The same operation as in Example (36b) was performed using NCS (1.35 g, 10.1 mmol), silver nitrate (2.45 g, 14.4 mmol), 2,2,2-trifluoro-1-(2-ethyl-1,3-dithian-2-yl)ethanone obtained in Example (39b) (1.0 g, 4.09 mmol), dimethoxyacetaldehyde (5.76 M aqueous solution, 1.0 mL, 5.76 mmol) and 28% aqueous ammonia (4 mL). The resulting compound was used for the next reaction without purification.

後処理

  1. customThe resulting compound was used for the next reaction without purification

出典と根拠

ORDレコード
ord-32c9d6fbc87e4f1f88b22aa950396e18
出典データセット
uspto-grants-2015_01
特許番号
US08927588B2

反応ノート

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