Methyl 5-methyl-2-(4-nitrophenyl)oxazole-4-carboxylate → Methyl 2-(4-aminophenyl)-5-methyl-1,3-oxazole-4-carboxylate
反応式
[CH3:1][C:2]1[O:6][C:5]([C:7]2[CH:12]=[CH:11][C:10]([N+:13]([O-])=O)=[CH:9][CH:8]=2)=[N:4][C:3]=1[C:16]([O:18][CH3:19])=[O:17]>[Pd].CO>[NH2:13][C:10]1[CH:9]=[CH:8][C:7]([C:5]2[O:6][C:2]([CH3:1])=[C:3]([C:16]([O:18][CH3:19])=[O:17])[N:4]=2)=[CH:12][CH:11]=1参加物
4
実験手順
The same operation as in Example (95b) was performed using methyl 5-methyl-2-(4-nitrophenyl)-1,3-oxazole-4-carboxylate obtained in Example (97c) (0.75 g, 2.86 mmol), 10% Pd/C (0.3 g) and methanol (10 mL). Purification by silica gel column chromatography (elution solvent: ethyl acetate/hexane=1/2, 1/1, 1/2, 1/4) gave 0.44 g of the title compound as a colorless solid (66%).
後処理
- customPurification
- washby silica gel column chromatography (elution solvent: ethyl acetate/hexane=1/2, 1/1, 1/2, 1/4)
出典と根拠
- ORDレコード
- ord-3d12256a683541588aae132b68750d03
- 出典データセット
- uspto-grants-2015_01
- 特許番号
- US08927588B2
反応ノート
読み込み中…