Methyl 2-(3-methoxy-4-nitrophenyl)-1,3-oxazole-4-carboxylate → Methyl 2-(4-amino-3-methoxyphenyl)-1,3-oxazole-4-carboxylate
反応式
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:12]2[O:13][CH:14]=[C:15]([C:17]([O:19][CH3:20])=[O:18])[N:16]=2)[CH:6]=[CH:7][C:8]=1[N+:9]([O-])=O>[Pd].C(O)C>[NH2:9][C:8]1[CH:7]=[CH:6][C:5]([C:12]2[O:13][CH:14]=[C:15]([C:17]([O:19][CH3:20])=[O:18])[N:16]=2)=[CH:4][C:3]=1[O:2][CH3:1]参加物
4
実験手順
The same operation as in Example (95b) was performed using methyl 2-(3-methoxy-4-nitrophenyl)-1,3-oxazole-4-carboxylate obtained in Example (102c) (1.46 g, 5.25 mmol), 10% Pd/C (0.3 g) and ethanol (20 mL). The resulting solid was washed with dichloromethane/hexane to obtain 0.88 g of the title compound as a colorless solid (67%).
後処理
- washThe resulting solid was washed with dichloromethane/hexane
出典と根拠
- ORDレコード
- ord-3b2d56f712dc49f69b18b5c2861e3d18
- 出典データセット
- uspto-grants-2015_01
- 特許番号
- US08927588B2
反応ノート
読み込み中…