cis(+/-)-N-benzyl-3-(2,2-difluoroethoxy)-1-(trifluoroacetyl)piperidin-4-amine → cis(+/-)-3-(2,2-Difluoroethoxy)-1-(trifluoroacetyl)piperidin-4-amine
反応式
C([NH:8][C@H:9]1[CH2:14][CH2:13][N:12]([C:15](=[O:20])[C:16]([F:19])([F:18])[F:17])[CH2:11][C@H:10]1[O:21][CH2:22][CH:23]([F:25])[F:24])C1C=CC=CC=1>[Pd].CO>[F:25][CH:23]([F:24])[CH2:22][O:21][C@H:10]1[C@@H:9]([NH2:8])[CH2:14][CH2:13][N:12]([C:15](=[O:20])[C:16]([F:19])([F:17])[F:18])[CH2:11]1参加物
4
実験手順
The same operation as in Example (95b) was performed using cis(±)-N-benzyl-3-(2,2-difluoroethoxy)-1-(trifluoroacetyl)piperidin-4-amine obtained in Example (121d) (1.1 g, 3 mmol), 10% Pd/C (wet, 0.35 g) and methanol (10 mL), to obtain 0.79 g of the title compound as a colorless oily substance (95%).
出典と根拠
- ORDレコード
- ord-0ab56ea9c9584e1e904192542351a663
- 出典データセット
- uspto-grants-2015_01
- 特許番号
- US08927588B2
反応ノート
読み込み中…