Sodium Carbonate → cis(+/-)-4-Chloro-N-(3-ethoxy-1-pyrimidin-2-ylpiperidin-4-yl)-5-ethyl-1H-imidazole-2-carboxamide

HRID 1425198ノート

反応式

HRID 1425198 の反応式
Cl.[Cl:2][C:3]1[N:4]=[C:5]([C:10]([NH:12][C@H:13]2[CH2:18][CH2:17][NH:16][CH2:15][C@H:14]2[O:19][CH2:20][CH3:21])=[O:11])[NH:6][C:7]=1[CH2:8][CH3:9].Cl[C:23]1[N:28]=[CH:27][CH:26]=[CH:25][N:24]=1.C(=O)([O-])[O-].[Na+].[Na+]>CN(C=O)C>[Cl:2][C:3]1[N:4]=[C:5]([C:10]([NH:12][C@H:13]2[CH2:18][CH2:17][N:16]([C:23]3[N:28]=[CH:27][CH:26]=[CH:25][N:24]=3)[CH2:15][C@H:14]2[O:19][CH2:20][CH3:21])=[O:11])[NH:6][C:7]=1[CH2:8][CH3:9]

参加物

5

反応物 3

HCID 10340Sodium CarbonateHCID 744042-ChloropyrimidineHCID 86648665cis(+/-)-4-Chloro-N-(3-ethoxypiperidin-4-yl)-5-ethyl-1H-imidazole-2-carboxamide hydrochloride

生成物 1

HCID 86648673cis(+/-)-4-Chloro-N-(3-ethoxy-1-pyrimidin-2-ylpiperidin-4-yl)-5-ethyl-1H-imidazole-2-carboxamide収率 22.3%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

cis(±)-4-Chloro-N-(3-ethoxypiperidin-4-yl)-5-ethyl-1H-imidazole-2-carboxamide hydrochloride obtained in Example (131a) (100 mg, 0.297 mmol), 2-chloropyrimidine (51 mg, 0.45 mmol) and sodium carbonate (157 mg, 1.48 mmol) were suspended in DMF (1 mL). The suspension was subjected to the same operation as in Example (131b) to obtain 25.1 mg of the title compound as a white solid (22%).

出典と根拠

ORDレコード
ord-dcf2b630ffd34ca1866a2d1d5ab309e7
出典データセット
uspto-grants-2015_01
特許番号
US08927588B2

反応ノート

読み込み中…