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tert-Butyl cis(+/-)-4-{[(benzyloxy)carbonyl]amino}-3-(dimethylamino)piperidine-1-carboxylate → tert-Butyl cis(+/-)-4-amino-3-(dimethylamino)piperidine-1-carboxylate

HRID 1425309
ノート
印刷プレビュー

反応式

HRID 1425309 の反応式
C(OC([NH:11][C@H:12]1[CH2:17][CH2:16][N:15]([C:18]([O:20][C:21]([CH3:24])([CH3:23])[CH3:22])=[O:19])[CH2:14][C@H:13]1[N:25]([CH3:27])[CH3:26])=O)C1C=CC=CC=1.[H][H]>CO.[OH-].[Pd+2].[OH-]>[NH2:11][C@H:12]1[CH2:17][CH2:16][N:15]([C:18]([O:20][C:21]([CH3:22])([CH3:23])[CH3:24])=[O:19])[CH2:14][C@H:13]1[N:25]([CH3:27])[CH3:26]
参加物実験手順後処理出典と根拠反応ノート

参加物

5

反応物 2

HCID 86648775tert-Butyl cis(+/-)-4-{[(benzyloxy)carbonyl]amino}-3-(dimethylamino)piperidine-1-carboxylateHCID 178418361HCID 178418361、化合物

生成物 1

HCID 86648776tert-Butyl cis(+/-)-4-amino-3-(dimethylamino)piperidine-1-carboxylate収率 100.3%

試薬・触媒・溶媒 2

HCID 9942167Palladium hydroxide触媒HCID 887Methanol溶媒

実験手順

20% Palladium hydroxide (15 mg) was added to a solution of tert-butyl cis(±)-4-{[benzyloxy)carbonyl]amino}-3-(dimethylamino)piperidine-1-carboxylate obtained in Example (200b) (144 mg, 0.381 mmol) in methanol (4 mL) at room temperature, and the mixture was stirred in a hydrogen atmosphere at 50° C. for six hours. The insoluble matter was separated by filtration, and the filtrate was concentrated under reduced pressure to obtain 93 mg of the title compound (100%) as a colorless oily substance.

後処理

  1. customThe insoluble matter was separated by filtration
  2. concentrationthe filtrate was concentrated under reduced pressure

出典と根拠

ORDレコード
ord-7b281f9757a54fbab899ae1f450baae7
出典データセット
uspto-grants-2015_01
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US08927588B2

反応ノート

読み込み中…

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