Sulfuric Acid → HCID 67996687、化合物

HRID 1425955ノート

反応式

HRID 1425955 の反応式
[Br:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2([C:11]#[N:12])[CH2:10][CH2:9]2)=[N:6][CH:7]=1.S(=O)(=O)(O)[OH:14].[OH-].[Na+]>>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2([C:11]([NH2:12])=[O:14])[CH2:9][CH2:10]2)=[N:6][CH:7]=1

参加物

4

反応物 3

HCID 1118Sulfuric AcidHCID 14798Sodium HydroxideHCID 534029901-(5-Bromopyridin-2-yl)cyclopropane-1-carbonitrile

生成物 1

HCID 67996687HCID 67996687、化合物

実験手順

A mixture of 1-(5-bromo-pyridin-2-yl)-cyclopropanecarbonitrile (0.18 g) and sulfuric acid (95%, 1.8 mL) was stirred at room temperature overnight. The solution was poured on crushed ice and the resulting solution was basified using 4 M aqueous NaOH solution. The solution was extracted with dichloromethane, the combined extracts were dried (Na2SO4), and the solvent was evaporated to give the title compound as a colorless solid. Yield: 0.20 g (quantitative); LC (method 2): tR=2.38 min; Mass spectrum (ESI+): m/z=241/243 (Br) [M+H]+.

後処理

  1. additionThe solution was poured
  2. customon crushed ice
  3. extractionThe solution was extracted with dichloromethane
  4. dry with materialthe combined extracts were dried (Na2SO4)
  5. customthe solvent was evaporated

出典と根拠

ORDレコード
ord-a268be6ce24a4d61a7c48ab513658c7d
出典データセット
uspto-grants-2015_01
特許番号
US08933072B2

反応ノート

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