Triethylamine → HCID 53404370、化合物

HRID 1426361ノート

反応式

HRID 1426361 の反応式
F[C:2](F)(F)[C:3]([O:5][C:6](=O)[C:7]([F:10])([F:9])[F:8])=[O:4].[CH3:14][C:15](C)=[CH:16]C(Cl)=O.C(N(CC)CC)C>C(Cl)(Cl)Cl>[CH3:14][C:15]1[CH:16]=[C:6]([C:7]([F:10])([F:9])[F:8])[O:5][C:3](=[O:4])[CH:2]=1

参加物

5

反応物 3

HCID 8471TriethylamineHCID 9845Trifluoroacetic anhydrideHCID 1023943-Methyl-2-butenoyl chloride

生成物 1

HCID 53404370HCID 53404370、化合物

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒

実験手順

To a solution of trifluoroacetic anhydride (10.63 g, 50.61 mmol) and 3,3-dimethylacryloyl chloride (5.0 g, 42 mmol) in chloroform (85 mL) at 0° C. was added triethylamine (12.91 mL, 92.60 mmol). The resulting reaction mixture was stirred at same temperature for 1 h, then allowed to warm to room temperature overnight. The reaction solution was washed with water (2×), saturated sodium bicarbonate, water, and brine, and then dried over Na2SO4, filtered and concentrated. The crude residue was used in next step.

後処理

  1. customThe resulting reaction mixture
  2. washThe reaction solution was washed with water (2×), saturated sodium bicarbonate, water, and brine
  3. dry with materialdried over Na2SO4
  4. filtrationfiltered
  5. concentrationconcentrated

出典と根拠

ORDレコード
ord-26faaa2f34564c4787b40085e37b2b05
出典データセット
uspto-grants-2015_01
特許番号
US08933085B2

反応ノート

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