Oxalyl chloride → (2E)-3-cyclopentylacryloyl chloride
反応式
[CH:1]1(/[CH:6]=[CH:7]/[C:8]([OH:10])=O)[CH2:5][CH2:4][CH2:3][CH2:2]1.C(Cl)(=O)C([Cl:14])=O>C(Cl)Cl>[CH:1]1(/[CH:6]=[CH:7]/[C:8]([Cl:14])=[O:10])[CH2:5][CH2:4][CH2:3][CH2:2]1参加物
4
反応条件
- 温度
- 0 °C
実験手順
To a solution of (2E)-3-cyclopentylacrylic acid (1.3 g, 9.3 mmol) in DCM (65 mL) at 0° C. was added oxalyl chloride (3.1 mL, 37 mmol), dropwise. The resulting solution was stirred at 0° C. for 40 minutes, then at room temperature for 2 hours. The volatiles were evaporated to afford (2E)-3-cyclopentylacryloyl chloride as a colorless liquid. A portion of this (2E)-3-cyclopentylacryloyl chloride (0.75 g, 4.7 mol) was dissolved in methanol (10 mL) and the resulting solution was stirred for 2 hours. The solvent was evaporated to afford the product (700 mg, 96%).
後処理
- waitat room temperature for 2 hours
- customThe volatiles were evaporated
出典と根拠
- ORDレコード
- ord-d5c8a82447fd439aa1c0626245503fc9
- 出典データセット
- uspto-grants-2015_01
- 特許番号
- US08933086B2
反応ノート
読み込み中…