Hydrogen Bromide → HCID 59826894、化合物

HRID 1426682ノート

反応式

HRID 1426682 の反応式
[F:1][C:2]1[C:7]([C:8](=[O:11])[CH2:9][CH3:10])=[CH:6][CH:5]=[CH:4][N:3]=1.[BrH:12].BrBr>C(O)(=O)C>[Br:12][CH:9]([CH3:10])[C:8]([C:7]1[C:2]([F:1])=[N:3][CH:4]=[CH:5][CH:6]=1)=[O:11]

参加物

5

反応物 3

HCID 260Hydrogen BromideHCID 24408BromineHCID 598268711-(2-Fluoro-3-pyridinyl)-1-propanone

生成物 1

HCID 59826894HCID 59826894、化合物

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

To a mixture of 1-(2-fluoropyridin-3-yl)propan-1-one (12.9 g) and 25% solution (70 mL) of hydrogen bromide in acetic acid was added dropwise bromine (4.4 mL), and the obtained mixture was stirred at room temperature for 3 hr. The reaction mixture was concentrated under reduced pressure to give the title compound as a red-brown oil (yield 29.6 g, quantitative).

後処理

  1. concentrationThe reaction mixture was concentrated under reduced pressure

出典と根拠

ORDレコード
ord-7ea1891125904c788398aec76e096f5d
出典データセット
uspto-grants-2015_01
特許番号
US08933105B2

反応ノート

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