Water → 5-Bromo-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-amine

HRID 1428123ノート

反応式

HRID 1428123 の反応式
[Br:1]N1C(=O)CCC1=O.[CH3:9][C:10]1([CH3:24])[C:14]([CH3:16])([CH3:15])[O:13][B:12]([C:17]2[C:18]([NH2:23])=[N:19][CH:20]=[CH:21][CH:22]=2)[O:11]1.O>CN(C=O)C>[Br:1][C:21]1[CH:22]=[C:17]([B:12]2[O:11][C:10]([CH3:24])([CH3:9])[C:14]([CH3:15])([CH3:16])[O:13]2)[C:18]([NH2:23])=[N:19][CH:20]=1

参加物

5

反応物 3

HCID 962WaterHCID 67184N-bromobutanimideHCID 438110672-Aminopyridine-3-boronic acid, pinacol ester

生成物 1

HCID 867000765-Bromo-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-amine収率 51.5%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

N-Bromosuccinimide (255 mg) was added to a solution of 3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-amine (300 mg) in DMF (6.8 ml) at room temperature, and the mixture was stirred for four hours. Water was added and the precipitated solid was collected by filtration to give 210 mg of the title compound.

後処理

  1. filtrationthe precipitated solid was collected by filtration

出典と根拠

ORDレコード
ord-4657539fb2ef4a72a457d2c930710a26
出典データセット
uspto-grants-2015_01
特許番号
US08933103B2

反応ノート

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