n-Butyl(S)-3-[(6-oxo-1,6-dihydro-pyridazine-4-carbonyl)-amino]-tetrahydrofuran-3-carboxylate → (S)-3-[(6-oxo-1,6-dihydro-pyridazine-4-carbonyl)-amino]-tetrahydrofuran-3-carboxylic acid

HRID 1428205ノート

反応式

HRID 1428205 の反応式
[O:1]=[C:2]1[NH:7][N:6]=[CH:5][C:4]([C:8]([NH:10][C@@:11]2([C:16]([O:18]CCCC)=[O:17])[CH2:15][CH2:14][O:13][CH2:12]2)=[O:9])=[CH:3]1>[OH-].[Na+]>[O:1]=[C:2]1[NH:7][N:6]=[CH:5][C:4]([C:8]([NH:10][C@@:11]2([C:16]([OH:18])=[O:17])[CH2:15][CH2:14][O:13][CH2:12]2)=[O:9])=[CH:3]1

参加物

3

反応物 1

HCID 68023757n-Butyl(S)-3-[(6-oxo-1,6-dihydro-pyridazine-4-carbonyl)-amino]-tetrahydrofuran-3-carboxylate

生成物 1

HCID 59496525(S)-3-[(6-oxo-1,6-dihydro-pyridazine-4-carbonyl)-amino]-tetrahydrofuran-3-carboxylic acid収率 71%

試薬・触媒・溶媒 1

HCID 14798Sodium Hydroxide溶媒

実験手順

n-Butyl(S)-3-[(6-oxo-1,6-dihydro-pyridazine-4-carbonyl)-amino]-tetrahydrofuran-3-carboxylate (21.0 g, 67.9 mmol) was stirred vigorously in 200 mL of 1N sodium hydroxide solution for 1 hour. The mixture was then extracted twice with 100 mL of diethyl ether, the alkaline aqueous phase was then combined with 50 mL of 4N hydrochloric acid. The mixture was then evaporated to dryness and the residue was stirred with 150 mL ethanol. Undissolved ingredients were then filtered off and the filtrate was evaporated down. In this way the product was obtained in a yield of 71% of theory. The product thus obtained was further processed without purification.

後処理

  1. extractionThe mixture was then extracted twice with 100 mL of diethyl ether
  2. customThe mixture was then evaporated to dryness
  3. filtrationwere then filtered off
  4. customthe filtrate was evaporated down
  5. customIn this way the product was obtained in a yield of 71% of theory
  6. customThe product thus obtained
  7. customwas further processed without purification

出典と根拠

ORDレコード
ord-9832b58a18594b9a85fca5add5a83dab
出典データセット
uspto-grants-2015_01
特許番号
US08937073B2

反応ノート

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