Water → 2-(Aminomethyl)-1,3-benzodioxole
反応式
[O:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[O:3][CH:2]1[C:10]([NH2:12])=O.[H-].[Al+3].[Li+].[H-].[H-].[H-].O>O1CCCC1>[O:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[O:3][CH:2]1[CH2:10][NH2:12]参加物
5
実験手順
Benzo[1,3]dioxole-2-carboxylic acid amide (5.44 g, 32.9 mmol) was dissolved in tetrahydrofuran (THF, 100 mL). Lithium aluminum hydride (LAH, 1M in THF, 39.5 mL, 39.5 mmol) was added slowly to the solution at room temperature. The reaction was stirred at room temperature for 24 hours. Distilled water was added to destroy the excess LAH. Aqueous sodium hydroxide (3.0 M, 100 mL) was added and the solution was extracted with ethyl acetate (3×100 mL). The combined organic solution was washed with water and dried over MgSO4. The solvent was evaporated to yield C-benzo[1,3]dioxol-2-yl-methylamine as a colorless oil.
後処理
- customto destroy the excess LAH
- additionAqueous sodium hydroxide (3.0 M, 100 mL) was added
- extractionthe solution was extracted with ethyl acetate (3×100 mL)
- washThe combined organic solution was washed with water
- dry with materialdried over MgSO4
- customThe solvent was evaporated
出典と根拠
- ORDレコード
- ord-abf95600aad94b74aacc98aa5a380858
- 出典データセット
- uspto-grants-2015_01
- 特許番号
- US08937096B2
反応ノート
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