Water → HCID 59457651、化合物
反応式
[Cl:1][C:2]1[N:7]=[C:6]([NH2:8])[CH:5]=[N:4][CH:3]=1.[I:9]N1C(=O)CCC1=O.O.C([O-])(O)=O.[Na+]>CS(C)=O>[Cl:1][C:2]1[N:7]=[C:6]([NH2:8])[CH:5]=[N:4][C:3]=1[I:9]参加物
6
実験手順
A solution of 6-chloropyrazin-2-amine (10.0 g, 77 mmol) in DMSO (100 ml) was treated with 1-iodopyrrolidine-2,5-dione (20.84 g, 93 mmol). The reaction mixture was stirred at RT for 2 days and then added to water (800 ml). The pH was adjusted to pH 8-9 using a sat. NaHCO3 solution and the resulting suspension was filtered, washing with water (×3) and dried under vacuum to afford the titled compound as an orange solid;
後処理
- filtrationthe resulting suspension was filtered
- washwashing with water (×3)
- customdried under vacuum
出典と根拠
- ORDレコード
- ord-4f72da9d330e42fc9906af4a07c4afc6
- 出典データセット
- uspto-grants-2015_01
- 特許番号
- US08937069B2
反応ノート
読み込み中…