Methyl 2-(3-fluoro-4-nitrophenyl)propanoate → Methyl 2-(4-amino-3-fluorophenyl)propanoate

HRID 1428780ノート

反応式

HRID 1428780 の反応式
[F:1][C:2]1[CH:3]=[C:4]([CH:11]([CH3:16])[C:12]([O:14][CH3:15])=[O:13])[CH:5]=[CH:6][C:7]=1[N+:8]([O-])=O>[Pd].CO>[NH2:8][C:7]1[CH:6]=[CH:5][C:4]([CH:11]([CH3:16])[C:12]([O:14][CH3:15])=[O:13])=[CH:3][C:2]=1[F:1]

参加物

4

反応物 1

HCID 13213768Methyl 2-(3-fluoro-4-nitrophenyl)propanoate

生成物 1

HCID 13758007Methyl 2-(4-amino-3-fluorophenyl)propanoate

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

10% Palladium on carbon is added to a solution methyl 2-(3-fluoro-4-nitrophenyl)propanoate in methanol and the mixture is charged with H2 (g). After stirring the reaction mixture for 6 h, the mixture is filtered using celite packed filter and purified by column chromatography to obtain methyl 2-(4-amino-3-fluorophenyl)propanoate.

後処理

  1. additionthe mixture is charged with H2 (g)
  2. filtrationthe mixture is filtered
  3. filtrationpacked filter
  4. custompurified by column chromatography

出典と根拠

ORDレコード
ord-c79403282ab543c7a07a96c1cda069c7
出典データセット
uspto-grants-2015_01
特許番号
US08937092B2

反応ノート

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