Sodium borohydride → 2-(4-(aminomethyl)-3-fluorophenyl)-N-((2-m-tolyl-6-(trifluoromethyl)pyridin-3-yl)methyl)propanamide

HRID 1428783ノート

反応式

HRID 1428783 の反応式
[C:1]([C:3]1[CH:8]=[CH:7][C:6]([CH:9]([CH3:31])[C:10]([NH:12][CH2:13][C:14]2[C:15]([C:24]3[CH:25]=[C:26]([CH3:30])[CH:27]=[CH:28][CH:29]=3)=[N:16][C:17]([C:20]([F:23])([F:22])[F:21])=[CH:18][CH:19]=2)=[O:11])=[CH:5][C:4]=1[F:32])#[N:2].[BH4-].[Na+]>C(O)C.[NiH6-5]Cl>[NH2:2][CH2:1][C:3]1[CH:8]=[CH:7][C:6]([CH:9]([CH3:31])[C:10]([NH:12][CH2:13][C:14]2[C:15]([C:24]3[CH:25]=[C:26]([CH3:30])[CH:27]=[CH:28][CH:29]=3)=[N:16][C:17]([C:20]([F:23])([F:21])[F:22])=[CH:18][CH:19]=2)=[O:11])=[CH:5][C:4]=1[F:32]

参加物

5

反応物 2

HCID 4311764Sodium borohydrideHCID 866802252-(4-cyano-3-fluorophenyl)-N-((2-m-tolyl-6-(trifluoromethyl)pyridin-3-yl)methyl)propanamide

生成物 1

HCID 866802262-(4-(aminomethyl)-3-fluorophenyl)-N-((2-m-tolyl-6-(trifluoromethyl)pyridin-3-yl)methyl)propanamide

試薬・触媒・溶媒 2

HCID 178479586HCID 178479586、化合物触媒HCID 702Ethanol溶媒

実験手順

Nickel(II) chloride hexahydride (1 equiv.) and 2-(4-cyano-3-fluorophenyl)-N-((2-m-tolyl-6-(trifluoromethyl)pyridin-3-yl)methyl)propanamide are stirred in anhydrous ethanol during 15 minute for activation. Sodium borohydrid (7 equiv.) is added on it and mixture stirred for 2 h. Adding celite to the reaction and filter it using celite packed filter, washing with ethanol. The reaction mixture is purified after concentration to obtain 2-(4-(aminomethyl)-3-fluorophenyl)-N-((2-m-tolyl-6-(trifluoromethyl)pyridin-3-yl)methyl)propanamide.

後処理

  1. additionAdding celite
  2. customto the reaction
  3. filtrationfilter it
  4. filtrationusing celite packed filter
  5. washwashing with ethanol
  6. customThe reaction mixture is purified
  7. concentrationafter concentration

出典と根拠

ORDレコード
ord-0ed009c570f74694a781f48e9162d621
出典データセット
uspto-grants-2015_01
特許番号
US08937092B2

反応ノート

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