Sodium Hydroxide → HCID 86688151、化合物

HRID 1428945ノート

反応式

HRID 1428945 の反応式
C([O:8][CH2:9][C:10]1[N:11]([CH2:23][CH3:24])[CH:12]=[C:13]([C:15]2[CH:20]=[CH:19][C:18]([F:21])=[C:17]([CH3:22])[CH:16]=2)[N:14]=1)C1C=CC=CC=1.[OH-].[Na+]>Cl>[CH2:23]([N:11]1[CH:12]=[C:13]([C:15]2[CH:20]=[CH:19][C:18]([F:21])=[C:17]([CH3:22])[CH:16]=2)[N:14]=[C:10]1[CH2:9][OH:8])[CH3:24]

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 86688149HCID 86688149、化合物

生成物 1

HCID 86688151HCID 86688151、化合物収率 96.9%

試薬・触媒・溶媒 1

HCID 313Hydrochloric Acid溶媒

実験手順

4 g 2-benzyloxymethyl-1-ethyl-4-(4-fluoro-3-methyl-phenyl)-1H-imidazole was stirred 24 h at 85° C. in 40 mL concentrated aqueous hydrochloride acid. The mixture was dropped in a cooled 10% aqueous sodium hydroxide solution. The precipitate was filtered, washed with water and dried at 50° C. to yield 2.8 g of the desired product. Rt: 0.60 min (method J), (M+H)+: 235

後処理

  1. filtrationThe precipitate was filtered
  2. washwashed with water
  3. customdried at 50° C.

出典と根拠

ORDレコード
ord-1c39913f53b4449aa2d0dd34bfcf9897
出典データセット
uspto-grants-2015_01
特許番号
US08937176B2

反応ノート

読み込み中…