Citric Acid → HCID 178493585、化合物
反応式
Cl[C:2]1[CH:7]=[C:6]([O:8][CH3:9])[N:5]=[C:4]([O:10][CH3:11])[N:3]=1.C1N2CCN(CC2)C1.C(=O)([O-])[O-:21].[K+].[K+].C(O)(=O)CC(CC(O)=O)(C(O)=O)O>O>[CH3:11][O:10][C:4]1[N:3]=[C:2]([OH:21])[CH:7]=[C:6]([O:8][CH3:9])[N:5]=1参加物
6
実験手順
A suspension of 4-chloro-2,6-dimethoxy-pyrimidine (4.9 g, 28 mmol), DABCO (6.4 g, 57 mmol) and potassium carbonate (13.8 g, 100 mmol) was refluxed in water (150 ml) for one hour. The mixture was cooled acidified with 5% citric acid and extracted three times with ethyl acetate and three times with DCM with about 105 THF and 10% MeOH. The combined organic phases were dried and evaporated which gave the title compound (1.5 g, 34%), (M+H)+1 157.
後処理
- temperatureThe mixture was cooled
- extractionextracted three times with ethyl acetate and three times with DCM with about 105 THF and 10% MeOH
- customThe combined organic phases were dried
- customevaporated which
出典と根拠
- ORDレコード
- ord-d6bed3b2bfe94e3ca2d89ac0f0149c68
- 出典データセット
- uspto-grants-2015_01
- 特許番号
- US08937080B2
反応ノート
読み込み中…