Bis(3-bromophenyl)methanol → Bis(3-bromophenyl)methanone
反応式
[Br:1][C:2]1[CH:3]=[C:4]([CH:8]([C:10]2[CH:15]=[CH:14][CH:13]=[C:12]([Br:16])[CH:11]=2)[OH:9])[CH:5]=[CH:6][CH:7]=1>ClCCl.O=[Mn]=O>[Br:1][C:2]1[CH:3]=[C:4]([C:8]([C:10]2[CH:15]=[CH:14][CH:13]=[C:12]([Br:16])[CH:11]=2)=[O:9])[CH:5]=[CH:6][CH:7]=1参加物
4
反応条件
- 温度
- 25 °C
実験手順
MnO2 (21.61 g, 249 mmol) was added to a solution of bis(3-bromophenyl)methanol (8.4 g, 24.5 mmol) in dichloromethane (80 mL). The mixture was stirred at 25° C. for 12 h and then filtered. The filter cake was washed with dichloromethane (60 mL×5). The filtrate was concentrated to afford 7.6 g of the title compound (22.3 mmol, 90%). LC/MS: [M+1]=341. 1H NMR (DMSO-d6), 400 MHz: δ 7.52-7.56 (m, 2H), 7.71 (d, 2H, J=7.2 Hz), 7.88-7.92 (m, 4H).
後処理
- filtrationfiltered
- washThe filter cake was washed with dichloromethane (60 mL×5)
- concentrationThe filtrate was concentrated
出典と根拠
- ORDレコード
- ord-da04784e106f48c4aeea7450e89e3e74
- 出典データセット
- uspto-grants-2015_01
- 特許番号
- US08937150B2
反応ノート
読み込み中…