Trifluoroacetic acid → 1((2-(Bromomethyl)benzyl)oxy)-3-(4-bromophenyl)propan-2-amine trifluoroacetic acid salt

HRID 1429365ノート

反応式

HRID 1429365 の反応式
C(OC(=O)[NH:7][CH:8]([CH2:20][C:21]1[CH:26]=[CH:25][C:24]([Br:27])=[CH:23][CH:22]=1)[CH2:9][O:10][CH2:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=1[CH2:18][Br:19])(C)(C)C.[C:29]([OH:35])([C:31]([F:34])([F:33])[F:32])=[O:30]>C(Cl)Cl>[F:32][C:31]([F:34])([F:33])[C:29]([OH:35])=[O:30].[Br:19][CH2:18][C:13]1[CH:14]=[CH:15][CH:16]=[CH:17][C:12]=1[CH2:11][O:10][CH2:9][CH:8]([NH2:7])[CH2:20][C:21]1[CH:26]=[CH:25][C:24]([Br:27])=[CH:23][CH:22]=1

参加物

4

反応物 2

HCID 6422Trifluoroacetic acidHCID 123844053tert-Butyl(1-((2-(bromomethyl)benzyl)oxy)-3-(4-bromophenyl)propan-2-yl)carbamate

生成物 1

HCID 673822521((2-(Bromomethyl)benzyl)oxy)-3-(4-bromophenyl)propan-2-amine trifluoroacetic acid salt収率 95%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

反応条件

温度
0 °C

実験手順

To a solution of compound 3i (2.2 g, 4.3 mmol) in DCM (20 mL) was added slowly TFA (2 mL) at 0° C. The mixture was stirred at 0° C. for 2 hr. LCMS analysis indicated the total consumption of compound 3i. The solvent was removed in vacuum to give 3k as a white solid (1.68 g, 95% yield).

後処理

  1. customthe total consumption of compound 3i
  2. customThe solvent was removed in vacuum

出典と根拠

ORDレコード
ord-2acb14afbf5a4ad8995a72ace2448417
出典データセット
uspto-grants-2015_01
特許番号
US08940722B2

反応ノート

読み込み中…