Trifluoroacetic acid → (S)-2-(N-(5-Amino-1-phenylpentan-2-yl)-2-(trifluoromethoxy)phenylsulfonamido)acetic acid

HRID 1429411ノート

反応式

HRID 1429411 の反応式
C(OC([NH:8][CH2:9][CH2:10][CH2:11][C@H:12]([N:20]([CH2:35][C:36]([OH:38])=[O:37])[S:21]([C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][C:25]=1[O:30][C:31]([F:34])([F:33])[F:32])(=[O:23])=[O:22])[CH2:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)=O)(C)(C)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[NH2:8][CH2:9][CH2:10][CH2:11][C@H:12]([N:20]([CH2:35][C:36]([OH:38])=[O:37])[S:21]([C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][C:25]=1[O:30][C:31]([F:33])([F:34])[F:32])(=[O:23])=[O:22])[CH2:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1

参加物

4

反応物 2

HCID 6422Trifluoroacetic acidHCID 71269086(S)-2-(N-(5-((tert-Butoxycarbonyl)amino)-1-phenylpentan-2-yl)-2-(trifluoromethoxy)phenylsulfonamido)acetic acid

生成物 1

HCID 71269357(S)-2-(N-(5-Amino-1-phenylpentan-2-yl)-2-(trifluoromethoxy)phenylsulfonamido)acetic acid

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To a solution of compound 31k (2.8 g, 5 mmol) in DCM (100 mL) was added TFA (20 mL). After the reaction was over, the solvents were removed by reduced pressure to give a white solid. The product was used in the next reaction step without further purification.

後処理

  1. customwere removed by reduced pressure
  2. customto give a white solid
  3. customThe product was used in the next reaction step without further purification

出典と根拠

ORDレコード
ord-3b8f6490e6204f158375e21699aaa1c0
出典データセット
uspto-grants-2015_01
特許番号
US08940722B2

反応ノート

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