Sodium Hydroxide → p-Methylphenoxyacetic acid

HRID 1429431

反応式

HRID 1429431 の反応式
[C:1]1([CH3:14])[CH:6]=[CH:5][C:4]([O:7][CH2:8][C:9]([O:11]CC)=[O:10])=[CH:3][CH:2]=1.[OH-].[Na+]>CCO>[C:1]1([CH3:14])[CH:6]=[CH:5][C:4]([O:7][CH2:8][C:9]([OH:11])=[O:10])=[CH:3][CH:2]=1

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 4047281(4-Methylphenoxy) acetic acid ethyl ester

生成物 1

HCID 70329p-Methylphenoxyacetic acid

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

To a solution of ethyl 2-(p-tolyloxy)acetate (200 mg, 1 mmol) in EtOH (10 ml) was added 10% NaOH solution (10 ml) at 26° C. The mixture was stirred for 30 min, concentrated then water (20 mL) added to it before washing with ethyl acetate (2×20 mL). The aqueous layer was acidified with 2N HCL until pH 3 and extracted with EA (2×20 ml). The organic layer was washed with brine (30 mL), dried over Na2SO4 and concentrated to give the title compound which was used in next step without further purification.

後処理

  1. concentrationconcentrated
  2. additionwater (20 mL) added to it
  3. washbefore washing with ethyl acetate (2×20 mL)
  4. extractionextracted with EA (2×20 ml)
  5. washThe organic layer was washed with brine (30 mL)
  6. dry with materialdried over Na2SO4
  7. concentrationconcentrated

出典と根拠

ORDレコード
ord-a411d46768aa47ae8ce8228d2a2c1153
出典データセット
uspto-grants-2015_01
特許番号
US08940726B2

関連ノート

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