Ethanol → 4-Methoxyphenoxyacetic acid

HRID 1429434

反応式

HRID 1429434 の反応式
C[C:2]([O:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)(C)[C:3]([O:5]CC)=[O:4].[OH-].[Na+].C[CH2:19][OH:20]>>[CH3:19][O:20][C:13]1[CH:12]=[CH:11][C:10]([O:9][CH2:2][C:3]([OH:5])=[O:4])=[CH:15][CH:14]=1

参加物

4

反応物 3

HCID 702EthanolHCID 14798Sodium HydroxideHCID 86476Deschloroclofibrate

生成物 1

HCID 746494-Methoxyphenoxyacetic acid

実験手順

To a solution of ethyl 2-methyl-2-phenoxypropanoate (210 mg, 1 mmol) in EtOH (10 ml) was added 10% NaOH aqueous solution (10 mL) at 26° C. The mixture was stirred for 30 min and then concentrated before the addition of water (20 mL) and washing with ethyl acetate (2×20 mL). The aqueous layer was acidified with 2N HCL until pH 3 and extracted with ethyl acetate (2×20 ml). The organic layer was washed with brine (30 mL), dried over Na2SO4 and concentrated to give the title compound which was used in next step without further purification.

後処理

  1. concentrationconcentrated before the addition of water (20 mL)
  2. washwashing with ethyl acetate (2×20 mL)
  3. extractionextracted with ethyl acetate (2×20 ml)
  4. washThe organic layer was washed with brine (30 mL)
  5. dry with materialdried over Na2SO4
  6. concentrationconcentrated

出典と根拠

ORDレコード
ord-23aa1f7efd7a4f46bed9eb2918d69118
出典データセット
uspto-grants-2015_01
特許番号
US08940726B2

関連ノート

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