tert-Butyl piperazine-1-carboxylate → tert-Butyl 4-(2-(1-(5-propylpyrimidin-2-yl)piperidin-4-yloxy)benzo[d]thiazol-6-yl)piperazine-1-carboxylate

HRID 1429529ノート

反応式

HRID 1429529 の反応式
Br[C:2]1[CH:26]=[CH:25][C:5]2[N:6]=[C:7]([O:9][CH:10]3[CH2:15][CH2:14][N:13]([C:16]4[N:21]=[CH:20][C:19]([CH2:22][CH2:23][CH3:24])=[CH:18][N:17]=4)[CH2:12][CH2:11]3)[S:8][C:4]=2[CH:3]=1.[N:27]1([C:33]([O:35][C:36]([CH3:39])([CH3:38])[CH3:37])=[O:34])[CH2:32][CH2:31][NH:30][CH2:29][CH2:28]1.CC(C)([O-])C.[Na+]>C1(C)C=CC=CC=1.O.C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.[Pd].[Pd].C1C=CC(P(C2C(C3C(P(C4C=CC=CC=4)C4C=CC=CC=4)=CC=C4C=3C=CC=C4)=C3C(C=CC=C3)=CC=2)C2C=CC=CC=2)=CC=1>[CH2:22]([C:19]1[CH:18]=[N:17][C:16]([N:13]2[CH2:14][CH2:15][CH:10]([O:9][C:7]3[S:8][C:4]4[CH:3]=[C:2]([N:30]5[CH2:29][CH2:28][N:27]([C:33]([O:35][C:36]([CH3:39])([CH3:38])[CH3:37])=[O:34])[CH2:32][CH2:31]5)[CH:26]=[CH:25][C:5]=4[N:6]=3)[CH2:11][CH2:12]2)=[N:21][CH:20]=1)[CH2:23][CH3:24]

参加物

8

反応物 3

HCID 143452tert-Butyl piperazine-1-carboxylateHCID 23676156Sodium t-butoxideHCID 674627936-Bromo-2-(1-(5-propylpyrimidin-2-yl)piperidin-4-yloxy)benzo[d]thiazole

生成物 1

HCID 68208554tert-Butyl 4-(2-(1-(5-propylpyrimidin-2-yl)piperidin-4-yloxy)benzo[d]thiazol-6-yl)piperazine-1-carboxylate収率 55.4%

試薬・触媒・溶媒 4

HCID 634876Binap, (A+-)-触媒HCID 9811564Bis(dibenzylideneacetone)palladium触媒HCID 962Water溶媒HCID 1140Toluene溶媒

反応条件

温度
80 °C

実験手順

To a degassed solution of 6-bromo-2-(1-(5-propylpyrimidin-2-yl)piperidin-4-yloxy)benzo[d]thiazole (360 mg, 0.831 mmol), tert-butyl piperazine-1-carboxylate (387 mg, 2.077 mmol), sodium tert-butoxide (319 mg, 3.32 mmol) and BINAP (10.4 mg, 0.017 mmol) in toluene (5.5 mL) was added Pd2(dba)3 (45.6 mg, 0.050 mmol). Upon completion of addition, the reaction mixture was stirred in a sealed vial at 80° C. overnight. At the conclusion of this period, the reaction mixture was cooled to rt, diluted with water and then extracted with EtOAc (3×5 mL). The combined organic layers were washed with saturated NaHCO3 (5 mL) and brine (5 mL), dried (Na2SO4), filtered, and then concentrated to yield the crude product. The crude product was purified by column chromatography (silica gel, hexanes-EtOAc gradient 0 to 60% EtOAc) to afford Compound 12A as a white solid (248 mg, 0.460 mmol, 55% yield). 1H NMR (500 MHz, chloroform-d) δ ppm 8.18 (2H, s), 7.54-7.61 (1H, m), 7.15-7.23 (1H, m), 6.99-7.07 (1H, m), 5.37-5.44 (1H, m), 4.17-4.27 (2H, m), 3.65-3.77 (2H, m), 3.55-3.65 (4H, m), 3.06-3.18 (4H, m), 2.42 (2H, t, J=7.6 Hz), 2.13-2.22 (2H, m), 1.89-2.00 (2H, m), 1.56-1.64 (2H, m), 1.50 (9H, s), 0.95 (3H, t, J=7.3 Hz). LC/MS (m/z)=539 (M+H)+.

後処理

  1. additionUpon completion of addition
  2. temperatureAt the conclusion of this period, the reaction mixture was cooled to rt
  3. extractionextracted with EtOAc (3×5 mL)
  4. washThe combined organic layers were washed with saturated NaHCO3 (5 mL) and brine (5 mL)
  5. dry with materialdried (Na2SO4)
  6. filtrationfiltered
  7. concentrationconcentrated
  8. customto yield the crude product
  9. customThe crude product was purified by column chromatography (silica gel, hexanes-EtOAc gradient 0 to 60% EtOAc)

出典と根拠

ORDレコード
ord-297f159302234dadb86d2036df6df096
出典データセット
uspto-grants-2015_01
特許番号
US08940716B2

反応ノート

読み込み中…