Trifluoroacetic acid → 6-Bromo-2-(piperidin-4-yloxy)thiazolo[4,5-b]pyridine

HRID 1429538ノート

反応式

HRID 1429538 の反応式
[Br:1][C:2]1[CH:3]=[C:4]2[S:10][C:9]([O:11][CH:12]3[CH2:17][CH2:16][N:15](C(OC(C)(C)C)=O)[CH2:14][CH2:13]3)=[N:8][C:5]2=[N:6][CH:7]=1.C(O)(C(F)(F)F)=O.BrC1C=CC2N=C(OC3CCNCC3)SC=2C=1>>[Br:1][C:2]1[CH:3]=[C:4]2[S:10][C:9]([O:11][CH:12]3[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]3)=[N:8][C:5]2=[N:6][CH:7]=1

参加物

4

反応物 3

HCID 6422Trifluoroacetic acidHCID 674668246-Bromo-2-(piperidin-4-yloxy)-benzothiazoleHCID 68208481tert-Butyl 4-(6-bromothiazolo[4,5-b]pyridin-2-yloxy)piperidine-1-carboxylate

生成物 1

HCID 674627896-Bromo-2-(piperidin-4-yloxy)thiazolo[4,5-b]pyridine

実験手順

Compound 21C was prepared from Compound 21B and TFA in a similar manner to the procedure described for Compound 1B in Example 1. LC/MS (m/z)=314 (M+H)+.

出典と根拠

ORDレコード
ord-f0817a01803f4defba993a9b685c8547
出典データセット
uspto-grants-2015_01
特許番号
US08940716B2

反応ノート

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